A Study on the Mechanism of the Protective Effect of GuangeFang on Sepsis‑Associated Acute Kidney Injury
  
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DOI:10.4103/2311-8571.328618
KeyWord:GuangeFang, Janus kinase 2, mammalian target of rapamycin, sepsis-associated acute kidney injury
     
AuthorInstitution
Shuo Lia a.Intensive Care Unit, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
Qing‑Quan Liua a.Intensive Care Unit, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
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Abstract:
      Objective: The objective of this study was to explore the mechanism of  Guan Gefang (GGF) ; raw rhubarb 30 g, cassia arboreal 30 g, raw oyster 30 g, ground elm 60 g, and dandelion 30 g) kidney protection. Materials and Methods: Thirty‑six Sprague Dawley rats were randomly divided into a control group (Group N), a sepsis control group (Group S), and a sepsis + GGF group (Group G). For Group N, 8 ml/kg 0.9% NaCl was used as an enema; for Group S, cecal ligation and puncture (CLP) method was used for modeling and 8 ml/kg 0.9% NaCl was used as an enema; and Group G, CLP was used for modeling and 8 ml/kg GGF was used as an enema. All of the enemas were applied once daily for 4 days. The indices of serum creatinine (SCr), blood urea nitrogen (BUN), uric acid (UA), mammalian target of rapamycin (mTOR), Janus kinase 2 (JAK2) were compared across each group. Results: Compared to Group S, Group G had lower levels of SCr, BUN, and UA(P < 0.05), while the activities of mTOR and JAK2 were significantly inhibited. Conclusion: GGF may have inhibited the JAK2 or mTOR signaling pathways to protect the rats’ kidneys, which had sepsis-associated acute kidney injury.
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