Exploring the Pathways and Targets of Shexiang Baoxin Pill for Coronary Heart Disease through a Network Pharmacology Approach
  
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DOI:10.4103/wjtcm.wjtcm_18_18
KeyWord:Coronary heart disease, network pharmacology, reverse docking, Shexiang Baoxin pill, similarity search
                       
AuthorInstitution
Shou-De Zhangac a.State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai;c.Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
Zhan-Hai Sua a.State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai
Rui-Hui Liub b.Department of Phytochemistry, School of Pharmacy, Second Military Medical University
Yan-Yan Diaoc c.Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
Shi-Liang Lic c.Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
Ya-Ping Huad d.Department of Clinical Science 2, Faculty of Medicine and Dentistry, University of Bergen, 5009, Norway
Hong-Lin Lic c.Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
Wei-Dong Zhangbc b.Department of Phytochemistry, School of Pharmacy, Second Military Medical University;c.Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
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Abstract:
      Objective: To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation (reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach. Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP. Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched. Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease. Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding “drug-target-pathway-disease” interaction network.
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