The Potential Effects and Use of Chinese Herbal Medicine Pine Pollen (Pinus pollen): A Bibliometric Analysis of Pharmacological and Clinical Studies
  
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DOI:10.4103/wjtcm.wjtcm_4_20
KeyWord:Bibliometric analysis, Chinese herbal medicine, pine pollen, Pinus pollen, skin disease
                          
AuthorInstitution
Shi-Bing Liangab a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing;b.College of Basic Medical Sciences, Shanxi University of Traditional Chinese Medicine, Taiyuan
Ning Liangac a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing;c.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing
Fan-Long Bua a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing
Bao-Yong Laiad a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing;d.The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China
Ya-Peng Zhanga a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing
Hui-Juan Caoa a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing
Yu-Tong Feia a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing
Nicola Robinsonae a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing;e.School of Health and Social Care, London South Bank University, London, UK
Jian-Ping Liuaf a.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing;f.Institute of Integrated Traditional Chinese Medicine and Western Medicine, Guangzhou Medical University, Guangzhou, China
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Abstract:
      The objectives of this study are to conduct a comprehensive literature search and bibliometric analysis to identify the breadth and volume of pharmacological and clinical studies on pine pollen (Pinus pollen) and to identify the potential effects and the use of pine pollen. Three Chinese electronic databases and two English electronic databases were searched for pharmacological and clinical studies on pine pollen. Data were extracted and analyzed and included publication year, authors,study type, pharmacological research topics or clinical diseases/conditions, usage and type of preparation, authors’ conclusions, and adverse effects. Of 239 publications identified, 180 were pharmacological studies, 37 were clinical trials, and 22 were reviews. Numbers of publications increased particularly from 2004 onward. The top 10 most frequent topics in pharmacological studies were immune regulation, antisenility, antioxidation, liver protection, inhibiting prostate hyperplasia, inhibiting tumor cell proliferation, lowering blood glucose, lowering blood lipids, antifatigue, and improving intestinal function. The top 10 most frequent clinical diseasestreated or where pine pollen was used as an adjuvant were bedsores, diaper dermatitis, hyperlipidemia, oral mucositis, eczema, hyperplasia of prostate, hypertension, prostatitis, type 2 diabetes mellitus, and radiodermatitis. Eight trialsreported no adverse events associated with pine pollen, one reported mild gastrointestinal reactions, but symptoms disappeared without special management. There have been an increasing number of publications on pine pollen during the past 20 years. Pharmacological studies have shown many potential benefits, and clinical studies have indicated some positive effects when it is either used as a single herb or as an adjuvant to treat disease. Its use as a topical agent, especially for skin diseases, was notable.
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